NOW:53122:USA01012
http://widgets.journalinteractive.com/cache/JIResponseCacher.ashx?duration=5&url=http%3A%2F%2Fdata.wp.myweather.net%2FeWxII%2F%3Fdata%3D*USA01012
27°
H 28° L 27°
Cloudy | 5MPH

Kidney Disease Progression Studied

Oct. 6, 2010

The Medical College of Wisconsin received a five-year, $1.6 million grant from the National Institutes of Health’s National Institute of Diabetes and Digestive and Kidney Diseases to investigate how cellular response to a protein called tumor necrosis factor (TNF)-alpha affects the progression of autosomal dominant polycystic kidney disease (ADPKD). Xiaogang Li, Ph.D., assistant professor of pediatric nephrology at the Medical College and researcher at Children’s Hospital of Wisconsin, is principal investigator for the grant.

A protein made by blood cells in response to infection, TNF-alpha has been found to promote cyst formation in kidneys. Dr. Li is studying how this protein may also contribute to slow the progression of ADPKD, a disease that is characterized by multiple cysts on the kidneys. As an inherited disease, ADPKD affects about one in every 1,000 Americans. Symptoms include abdominal pain or tenderness, blood in urine, excessive urination at night, drowsiness and high blood pressure.

By studying the effect of the TNF-alpha signaling pathway on ADPKD, Dr. Li hopes to establish a foundation for developing effective treatments and therapies to slow the disease’s progression.

This site uses Facebook comments to make it easier for you to contribute. If you see a comment you would like to flag for spam or abuse, click the "x" in the upper right of it. By posting, you agree to our Terms of Use.

Suburban News Roundup

E-mail Newsletter

Your link to the biggest stories in the suburbs delivered Thursday mornings.


Enter your e-mail address above and click "Sign Up Now!" to begin receiving your e-mail newsletter
Get the Newsletter!

Login or Register to manage all your newsletter preferences.

Community Watch

» Wisconsin Guard medic honored for saving woman's life 12/18

» Westbound I-94 near Miller Park to close for 31 hours beginning Friday night 12/18

» Supreme Court grants expungement to young pot offender, reversing Court of Appeals 12/18

» Big 4th quarter sparks BC victory 12/16

» Central boys pull away in fourth quarter 12/16

» Council approves key steps for luxury apartment project 12/16

» Brookfield Central alum publishes first book 12/16

» Brookfield cheer squad dances way to worlds 12/14

» Brookfield Elementary reports cases of strep throat 12/10

» Elmbrook School District approves fee-based preschool option, registration to open Feb. 5 12/9

» Elmbrook Humane Society waives adoption fees for the holidays thanks to donation 12/9

» Wheelchair athletes finally get home games 12/9

» Elmbrook Humane Society waives adoption fees for the holidays 12/8

» United Way agencies in Milwaukee, Waukesha announce merger Updated:  12/4

» Sharon Lynne Wilson Center to celebrate its first published book, 'The Fire Keepers' 12/4

» As family dealership owner, she's the top 'nice guy' at Soerens Ford 11/29

» Woman who left gun in Brookfield church faces new charge 11/28

» Elm Grove approves 2015 budget, 1.03 percent levy increase 11/25

» Elmbrook Education Foundation's annual Ladies Night fundraiser to help meet $100K goal 11/25

» Anti-OWI Roll Call at Goerke's Corners 11/24

» Elmbrook's Fairview South School to hold Silent Auction and Craft Fair to raise funds for wheelchair-accessible van 11/19

» Brookfield delays financial assistance decision as aldermen request more information 11/19

» Brookfield's 2015 budget unanimously approved 11/18

» Stores to open doors earlier on Thanksgiving at Brookfield Square 11/17

» Brookfield, Elm Grove, New Berlin businesses team up to fill local food pantry 11/16

View All Posts Got a tip? Welcome rss

Advertisement

Deal Watch - Milwaukee

Milwaukee's Best Discounts & Deals

Advertisement

Local Business Directory

CONNECT